Turkey Tail Mushroom - Trametes versicolor

The turkey tail mushroom or cloud mushroom, Trametes versicolor has been studied and been shown to have anti-tumor property against many types of cancers. Ethanolic extracts of Yunzhi, a proprietary dietary supplement prepared from extracts of T. versicolor reduces the growth of hormone responsive prostate cancer LNCaP cell growth. The polysaccharo-peptide in the extract raises the possibility that Yunzhi may be considered as an adjuvant therapy in the treatment of hormone responsive prostate cancer; additionally, it may have chemo preventive potential to restrict prostate tumorigenic progression from the hormone-dependent to the hormone-refractory state.1 The growth of several human cancer cell lines, viz., gastric cancer (7907), lung cancer (SPC), leukemia (MCL), and lymphoma (SLY)-was markedly inhibited by a crude C. versicolor extract at 1 mg/mL after 72 h of incubation. 2 The polysaccharide peptide krestin of T. versicolor has potential to be used as an adjuvant in breast cancer prevention.3 The polysaccharide of this mushroom has been demonstrated to inhibit the proliferation of cancer cells in vitro and in vivo, examined on the human hepatoma cancer (QGY) cell lines. These results showed that the polysaccharide inhibited the proliferation in low concentrations (20 mg/L) and the IC50 value was 4.25 mg/L. Apoptosis and significant decrease in the expression of the cell cycle-related genes (p53, Bcl-2, and Fas,) in these cells following treatment, indicate that the polysaccharide can be a potential candidate in cancer therapy. 4

    Suggested Tincture Dosing is 1-4 ml daily. Start slowly as allergies and intolerances are always possible. Do not combine with Cyclophosphamide or Tamoxifen unless under a physician’s supervision. May lower blood sugar levels.

    Disclaimer: These statements have not been evaluated by the FDA and are not intended to diagnose or treat any illness.

    1 Chu, Kevin KW, Susan SS Ho, and Albert HL Chow. "Coriolus versicolor: a medicinal mushroom with promising immunotherapeutic values." The Journal of Clinical Pharmacology 42, no. 9 (2002): 976-984.
    2 Standish, Leanna J., Cynthia A. Wenner, Erin S. Sweet, Carly Bridge, Ana Nelson, Mark Martzen, Jeffrey Novack, and Carolyn Torkelson. "Trametes versicolor mushroom immune therapy in breast cancer." Journal of the Society for Integrative Oncology 6, no. 3 (2008): 122.
    3 He, Zhicheng, Jian Lin, Yingying He, and Shubai Liu. "Polysaccharide-peptide from Trametes versicolor: the potential medicine for colorectal cancer treatment." Biomedicines 10, no. 11 (2022): 2841.
    4 Cai, Xinzhong, Yan Pi, Xin Zhou, Lifen Tian, Shouyi Qiao, and Juan Lin. "Hepatoma cell growth inhibition by inducing apoptosis with polysaccharide isolated from Turkey tail medicinal mushroom, Trametes versicolor (L.: Fr.) Lloyd (Aphyllophoromycetideae)." International Journal of Medicinal Mushrooms 12, no. 3 (2010).